The Truth About Turmeric, Black Pepper, Broccoli, Sprouts, and other Toxins This is built on science-based pathways and mechanisms, not cherry-picked studies or biased narratives. Its purpose is to break down how compounds like turmeric, black pepper, broccoli, and sprouts affect the body—not through a marketing lens but through their biological actions. The focus is on pure biochemistry and physiology to show: 1. How these compounds damage cells and activate survival pathways. 2. Why these pathways, such as NRF2, are triggered by harm, not health. 3. How the body can naturally optimize detoxification and antioxidant defenses without relying on harmful toxins. 4. Why nutrient-dense animal-based foods provide direct support without stress. By the end of this, it will be clear that the body doesn’t need toxic compounds to thrive. Instead, a combination of nourishment and natural hormetic (mild stress) practices can sustain optimal cellular health. How Toxins Activate NRF2 and KEAP1 The NRF2 pathway is the body’s emergency response system for dealing with oxidative stress and toxins. When the body detects damage—whether from plant toxins, heavy metals, or other insults—this pathway activates to protect cells. However, this activation is a reaction to harm, not evidence of improved health. A. The KEAP1-NRF2 Pathway 1. Under Normal Conditions: • KEAP1 (Kelch-like ECH-associated protein 1) binds to NRF2, keeping it inactive in the cytoplasm. • KEAP1 acts as a sensor for oxidative stress or electrophilic toxins (reactive molecules that damage cells). 2. When Toxins Are Detected: • Reactive oxygen species (ROS) or electrophilic toxins (e.g., sulforaphane, curcumin, arsenic, piperine) disrupt KEAP1, releasing NRF2. • NRF2 moves into the nucleus and binds to antioxidant response elements (AREs) in DNA, activating genes that produce: • Glutathione (GSH): The body’s master antioxidant. • Phase II detox enzymes: Enzymes that neutralize and excrete toxins. • Catalase and Superoxide Dismutase (SOD): Enzymes that reduce oxidative damage.

For context I am allergic to eggs both the yolk and white. My diet right now is 2lb of Beef and 1lb of sweet potato. I'm 5"7 153lb at ~16% body fat. My goal is to shred down to 10% bodyfat. With my current diet I feel really good but haven't been losing those few pounds of fat. I'm considering eating only beef but I fear I might not be getting enough micro nutrients without eggs. Thanks for reading