Easily. Taken close to failure a single push/pull/leg split will give hypertrophy gains for beginners through intermediates getting you pretty close to a genetic maximum.
Once a week is a good start, but I would recommend at least a total body routine first with calisthenics first (Upper Push- Push Ups, Upper Pull- Pull Ups(Assisted if you can't do full range of motion pullups first), Lower Push- Squats, Lower Pull- Dumbell/Barbell Romanian Deadlifts), Corrective Exercises- Face Pulls for upper back, Glute Ham Raise for lower back, Offset Lunges/Jane Fonda Leg Raises for Glute Medius).
I know this is a bit long, but just a recommendation.