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Not well - Mistletoe Therapy
I’ve not been well for the past 4 days. I did have diarrhoea and fatigue last week and it’s continued this week as well. I might have picked up a bug form a school carol service or the Iscador Qu is really reacting with me. I do have very inflamed and tender injection sites.
ChatGPT asked about 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs in development
what drugs have been made like 6-diazo-5-oxo-L-norleucine ChatGPT said: 6-Diazo-5-oxo-L-norleucine (DON) is a glutamine antagonist that inhibits glutamine-utilizing enzymes and has been explored as an antitumor agent. Several drugs and analogs have been developed based on DON's mechanism of action or structural modifications to improve efficacy, reduce toxicity, and enhance delivery. Some of these include: DON Derivatives and Prodrugs: 1. JHU083 – A prodrug of DON designed to improve its pharmacokinetics and tumor targeting while reducing systemic toxicity. 2. DRP-104 (Sirpiglenastat) – A next-generation prodrug of DON with enhanced delivery to tumors, currently being studied for cancer treatment. 3. EDO-S101 – A fusion of alkylating agents with DON’s core structure, aiming for dual antitumor activity. Similar Glutamine Antagonists: 4. Azaserine – A structurally related glutamine analog that inhibits glutamine-utilizing enzymes, studied for its anticancer properties. 5. Acivicin – A glutamine antagonist that inhibits glutamine-dependent enzymes but was found to have toxicity limitations. Other Glutamine Metabolism Inhibitors (Mechanistically Related): 6. CB-839 (Telaglenastat) – A glutaminase inhibitor that disrupts cancer cell metabolism and has been tested in clinical trials. 7. L-γ-Glutamyl-p-nitroanilide (GPNA) – A selective inhibitor of glutamine transporters rather than glutamine-utilizing enzymes. 8. DON-PEGylated Compounds – Variations of DON with polyethylene glycol (PEG) conjugation to improve solubility and reduce toxicity.
Is This YouTuber Spreading Big Pharma Propaganda?
His YouTube title: Ketosis (Fasting/Ketogenic Diet) accelerates Cancer Growth - New Study. If not, he must be living under a rock if he doesn't know about Prof Seyfried, Dr. Dominic D'Agostino, and many reputable researchers who understand the science behind the ketogenic diet. In a time when C patients are fighting for their lives and searching for hope in ketogenic diet and other metabolic therapies, does this YouTuber muddy the waters even more? 😔 Patients deserve clarity, not confusion. BUT... the good thing is that in the comment section, some folks in the know have pushed back on his narrative. As a follower of Prof Seyfried’s metabolic principle, I gave this YouTuber a thumbs down. What is your take? https://www.youtube.com/watch?v=joa0zk8sb1E&t=161s
Helpful diagrams and flow charts
Hi everyone, this article on the ReDO protocol has helpful visuals to show you how each drug and nutraceutical comes into play at different stages of the cell cycle in a basal state. Figure 2 and 3 are particularly helpful. https://www.nature.com/articles/s41392-024-01808-1
Helpful diagrams and flow charts
Mistletoe therapy
I just started a mistletoe therapy. Anyone else?
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Cancer Warriors
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Science-based group helping people navigate cancer through metabolic therapy, nutrition and integrative treatments
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