UnitedHealthcare (UNH) CEO Brian Thompson has been killed

UnitedHealthcare CEO Brian Thompson has been killed in what investigators suspect was a targeted shooting outside a Manhattan hotel where the US health insurer was holding an investor conference.

The killing was a "brazen, targeted attack", New York City Police Commissioner Jessica Tisch said.

Thompson, 50, was set to speak at an investor meeting when he was gunned down about 6.45am (8.45pm AEDT) on Wednesday outside the New York Hilton Midtown by a shooter who fled on foot and then took an e-bike into Central Park, according to the New York Police Department.

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